Crystal structures of tolfenamic acid polymorphic forms I and II with precise hydrogen-atom positions for nuclear magnetic resonance studies


Acta Cryst. E76, 1421–1426 (2020)

C4X Discovery has developed pioneering methods for routinely determining single-crystal structures on sub-milligram quantities of material, allowing us to measure and use this complementary conformational data very early in our programmes. In this report, we grow large crystals of two polymorphs of tolfenamic acid and solve their structures to high enough resolution that the hydrogen positions can be precisely determined. We use such data to refine our solution free ligand dynamic structures determined by NMR.